Xintela’s operations are based on a patented technology platform, XINMARK™, from which the company makes use of specific markers to develop new treatments and diagnostics in regenerative medicine and cancer.
XINMARK™ is the key in Xintela’s operations and is the company’s patented marker technology. Xintela’s markers are specific proteins which work as ”recognition flags” on the surface of certain cells. The markers make it possible to identify and select certain types of stem cells which can develop inte cartilage cells. Thus, Xintela can provide an unique way of ensuring the quality of stem cells to be used in repairing damaged cartilage.
XINMARK™-technology also provides a means to detect certain tumour cells and to target treatment to the cells in order to slow tumour growth. Xintela is focussing on the treatment of the aggressive brain tumour glioblastoma. The technology can potentially be used in other indications in the future.
Xintela is developing an analytical test, XACT™ (Xintela Assay for Cell Therapy), which is based on specific antibodies which bind to Xintela’s markers. XACT™ is used in the quality assurance of methods and cells in the company’s own development activities for stem cell products but also in strategic collaborations with other companies and research groups. These collaborations aim to provide early revenues for Xintela, while increasing interest in the company’s technology.
Xintela’s technology platform is protected by over 50 approved patents in important markets and the company will submit further applications in 2016/2017.
Camper, L., Hellman, U. and Lundgren-Åkerlund, E. Isolation, "Cloning, and Sequence Analysis of the Integrin Subunit α10, a β1-associated Collagen Binding Integrin Expressed on Chondrocytes." Journal of Biological Chemistry 273, 20383–20389 (1998).
Camper, L., Holmvall, K., Wängnerud, C., Aszódi, A. and Lundgren-Åkerlund, E. "Distribution of the collagen-binding integrin α10β1 during mouse development." Cell Tissue Res. 306, 107-116 (2001).
Bengtsson, T., Camper, L., Schneller, M. and Lundgren-Åkerlund, E. "Characterization of the mouse integrin subunit α10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants." Matrix Biology 20, 565–76 (2001).
Bengtsson, T., Aszódi. A., Nicolae, C., Hunziker, E.B., Lundgren-Åkerlund, E. and Fässler, R. "Loss of α10β1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. " Journal of Cell Science 118, 929–36 (2005).
Varas, L., Bryngelson Ohlsson, L., Honeth, G., Olsson, A., Bengtsson, T., Wiberg, C., Bockermann, R., Järnum, S., Richter, J., Pennigton, D., Johnstone, B. Lundgren-Åkerlund, E and Kjellman, C. "α10 Integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential. " Stem Cells and Development 16, 965–978 (2007).
Lundgren-Åkerlund E, Aszòdi A. "Integrin α10β1: a collagen receptor critical in skeletal development" Adv Exp Med Biol. 819:61-71. (2014)
Zeltz C, Lu N, Gullberg D. “Integrin α11β1: a major collagen receptor on fibroblastic cells" Adv Exp Med Biol. 819:73-83. (2014)